Rebuilding injured vertebrae by different kinds of bone graft materials to treat thoracoiumbar burst fractures: an imaging verification of bone healing

doi:10.3969/j.issn.2095-4344.2014.39.001

Abstract

Abstract:

BACKGROUND: Intravertebral bone graft to rebuild anterior and middle column structure and to recover vertebral morphology has been re-understood, and a suitable bone graft material can promote bone healing and be conducive to rebuild the long-term stability of the spine.
OBJECTIVE: To discuss the differences in clinical efficacy of three kinds of bone graft materials through unilateral pedicle to treat thoracolumbar burst fractures.
METHODS: Totally 102 thoracolumbar burst fracture patients were randomized into three groups: autologous bone, autologous bone combined with allogeneic bone and allogeneic bone were implanted via the unilateral pedicle, respectively, in the three groups. We measured the percentage of height of the anterior edge of vertebral body and Cobb angle by X-Ray before and after bone grafting, and used CT to observe bone graft healing, and used Mimics to measure the defect area of vertebral body at the last follow-up.
RESULTS AND CONCLUSION: All the 102 patients were followed-up for 24-36 months. The percentage of height of the anterior edge of vertebral body and Cobb angle of three groups were restored after bone grafting (P < 0.05), but there was no difference in the percentage of height of the anterior edge of vertebral body of three groups at different time point after bone grafting. The Cobb angle in the allogeneic bone group was bigger than that in the autologous bone group and autologous bone combined with allogeneic bone group at 9, 12 and 24 months after bone grafting (P < 0.05). The fracture healing rate of the allogeneic bone group at different time points was lower than that of the autologous bone group and autologous bone combined with allogeneic bone group (P < 0.05), and the area of bone defect was bigger than that in the autologous bone group and autologous bone combined with allogeneic bone group (P < 0.05). These findings indicate that these three bone graft materials can rebuild the vertebral body via the unilateral pedicle to treat thoracolumbar burst fracture, reduce the loss of vertebral height and Cobb angle, and decrease defect area of the vertebral body. The clinical efficacy of autologous bone combined with allogeneic bone to heal bone graft and reduce bone defect is similar to autologous bone, both of which are better than allogeneic bone alone.

中国组织工程研究杂志出版内容重点：生物材料；骨生物材料; 口腔生物材料; 纳米材料; 缓释材料; 材料相容性；组织工程

全文链接：

Key words: biocompatible materials, fractures, bone transplantation

CLC Number:

R318

Shi Xiao-lin, Liu Qing-ge, Zhang Hao, Tian Yue, Yang Yong-ming, Yuan Wei-dong. Rebuilding injured vertebrae by different kinds of bone graft materials to treat thoracoiumbar burst fractures: an imaging verification of bone healing[J]. Chinese Journal of Tissue Engineering Research, 2014, 18(39): 6233-6239.

Figures/Tables 5

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